期刊
INTERNATIONAL IMMUNOLOGY
卷 25, 期 4, 页码 207-214出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxs116
关键词
Crohns disease; inflammasome; NLRP6; NOD2; microbiome
类别
资金
- National Institutes of Health [R01DK074738]
- Broad Medical Research Program of the Eli and Edythe L. Broad Foundations [IBD-0328]
- Cancer Research Institute
- Claudia Adams Barr Award
- Crohn's and Colitis Foundation of America
Regulation of intestinal microbiota by NLR proteins.The human intestine harbors a diverse microbial community consisting of a large number of bacteria and other micro-organisms that have co-evolved with the host intestinal immune system. During this process, microbiota and the host immune system shape one another by various mechanisms to achieve a successful symbiotic relationship. An increasing amount of evidence suggests that dysbiosisuthe breakdown of such harmonized colonizationumay result in infectious and inflammatory disorders, and recent advances in our studies indicate that receptors such as Toll-like receptors and NLR (nucleotide-binding oligomerization domain-like receptor; or nucleotide-binding domain- and leucine-rich repeat-containing receptor) proteins that detect micro-organisms and their products play a critical role in maintaining intestinal homeostasis. In this review, we summarize the role of NLR proteins in the regulation of intestinal microbiota. NLR proteins belong to a diverse family of cytoplasmic microbial sensors, mutations of which are involved in various disorders, including inflammatory bowel diseases. Understanding of the different roles of NLR family proteins in the intestine is, therefore, an important step towards the development of therapeutics against digestive diseases.
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