期刊
INTERNATIONAL IMMUNOLOGY
卷 22, 期 8, 页码 619-625出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxq053
关键词
CD8 T cell; CTL; differentiation; memory
类别
资金
- National Institutes of Health [AI051583, AI076457, AI041576, AI078289, P01 AI056172, F32 AI074277]
Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.
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