期刊
INTERNATIONAL IMMUNOLOGY
卷 21, 期 4, 页码 317-337出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxp017
关键词
innate immunity; NOD-like receptor; RIG-I-like receptor; signal transduction; Toll-like receptor
类别
资金
- NIH [PO1 AI070167]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
The mammalian innate immune system detects the presence of microbial infection through germ line-encoded pattern recognition receptors (PRRs). Toll-like receptors, retinoic acid-inducible gene-I-like receptors and nucleotide-binding oligomerization domain-like receptors serve as PRRs that recognize different but overlapping microbial components. They are expressed in different cellular compartments such as the cell surface, endosome, lysosome or cytoplasm and activate specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes. This review summarizes recent insights into pathogen sensing by these PRRs and their signaling pathways.
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