期刊
INTERNATIONAL IMMUNOLOGY
卷 20, 期 3, 页码 337-343出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxm147
关键词
antigen-presenting cell; infectious disease; protozoan parasite; T-h
类别
The onset of T(h)1 immunity is in part regulated by genetic background. To elucidate the cell type carrying critical factors determining the T(h)1 response, we employed Rag-2(-/-) mice on Leishmania major-susceptible BALB/c and -resistant B10.D2 backgrounds. By using bone marrow (BM) chimeras generated by the transplantation of B10.D2 BM cells into BALB/c-Rag-2(-/-) mice, and vice versa, it was shown that hematopoietic cells carry factors determining the disease outcome and T(h)1 response against L. major infection. B10.D2-Rag-2(-/-) mice reconstituted with BALB/c CD4(+) T cells exhibited a T(h)1 response and controlled L. major infection. Wild-type BALB/c mice inoculated with L. major-parasitized B10.D2-Rag-2(-/-) splenocytes also exhibited a T(h)1 response and a mild disease outcome, whereas such a T(h)1 response was not induced when CD11c(+) dendritic cells (DCs) were depleted from parasitized B10.D2-Rag-2(-/-) splenocytes. T(h)1 response was reconstituted by the addition of L. major-parasitized B10.D2 DCs but not L. major-parasitized BALB/c DCs to DC-depleted parasitized B10.D2-Rag-2(-/-) splenocytes. These results indicate that DCs determine the outcome of the disease upon L. major infection.
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