4.2 Article

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

期刊

INTERNAL MEDICINE
卷 52, 期 19, 页码 2173-2178

出版社

JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.52.8572

关键词

endothelial dysfunction; FMD; diabetic retinopathy

资金

  1. Turkish Ophthalmology Society

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Objective Endothelial dysfunction plays an important role in the development of diabetic retinopathy. The aim of this study was to evaluate endothelial dysfunction using different approaches in patients with type 1 diabete mellitus with early stages of diabetic retinopathy. For this purpose, we investigated the serum levels of cellular adhesion molecules, including intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and endothelin-1 (ET-1), which have emerged as specific markers of endothelial dysfunction, and measured the flow-mediated dilatation (FMD), a noninvasive technique used to evaluate endothelial dysfunction. Methods The study group included 59 patients with type 1 diabetes mellitus (DM) and 30 age-matched healthy control subjects. The diabetic patients were divided into two groups according to the ophthalmoscopic findings: Group 1, composed of type 1 diabetic patients having no signs of diabetic retinopathy (DRP), and Group 2, composed of type 1 diabetic patients having findings of the early stages of nonproliferative diabetic retinopathy (NPDR). Results The serum levels of ET-1 (fmol/mL), ICAM-1 (ng/mL) and VCAM-1 (ng/mL) were 8.52 +/- 0.699 vs. 478.39 +/- 46.22 vs. 728.64 +/- 35.081 in the patients without retinopathy, 8.91 +/- 1.354 vs. 451.79 +/- 48.262 vs. 863.59 +/- 62.37 in the diabetic patients with NPDR and 10.73 +/- 1.04 vs. 608.15 +/- 74.92 vs. 872.95 +/- 57.63 in the control group. There were no significant differences in the serum levels of the three molecules between the groups. The FMD values were 6.51 +/- 0.46% in the diabetic patients without retinopathy, 6.66 +/- 0.29% in the diabetic patients with NPDR and 6.68 +/- 0.51% in the control group. No significant differences were found between the groups. Conclusion The early stages of diabetic retinopathy cannot be considered in the evaluation of systemic markers of endothelial dysfunction.

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