期刊
INTERNAL MEDICINE
卷 50, 期 15, 页码 1569-1574出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.50.5166
关键词
Type 2 diabetes mellitus; periodontitis; insulin resistance; adiponectin; inflammatory cytokines
资金
- Zhejiang Science and Technology Projects [2009C33168]
- Natural Science Foundation of Zhejiang Province [Y2100077]
- Zhejiang Education Committee [Y201017607]
- National Natural Science Foundation of China [30872884]
- Zhejiang Health Bureau Fund [2009A104]
Objective To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. Methods and Patients A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patients with periodontitis were randomly divided into two groups according to whether they underwent periodontal intervention: T2DM-NT and T2DM-T group. The levels of serum adiponectin, C-reactive protein (CRP), tumor necrosis factor a (TNF-alpha), interleukin-6 (IL-6), lipid profile, glucose, insulin, homeostasis model of assessment - insulin resistance (HOMA-IR) and homeostasis model assessment of beta-cell function (HOMA-beta) were measured at baseline and after 3 months. Results The levels of clinical periodontal variables, the probing depth, attachment loss, bleeding index, and plaque index were improved significantly in T2DM-T group after 3 months compared to T2DM-NT group (all p<0.01). After 3 months, the serum levels of hsCRP, TNF-alpha, IL-6, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and HOMA-IR index decreased, and adiponectin was significantly increased in T2DM-T group compared to those in the T2DM-NT group (p<0.05 or p<0.01). Conclusion Periodontal intervention can improve glycemic control, lipid profile and IR, reduce serum inflammatory cytokine levels and increase serum adiponectin levels in moderately poorly controlled T2DM patients.
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