期刊
INTERNAL MEDICINE
卷 50, 期 7, 页码 739-744出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.50.4876
关键词
AA amyloidosis; pancreatitis; rheumatoid arthritis
资金
- Intractable Disease Division of the Ministry of Health and Welfare of Japan
- Research Committee for Epochal Diagnosis and Treatment for Amyloidosis in Japan
We report three cases of fatal pancreatitis associated with systemic AA amyloidosis in rheumatoid arthritis (RA). All of the patients showed end-stage renal failure, and hemodialysis was introduced during the course of treatment. Autopsy was performed on two of the three patients, and this revealed amyloid deposition on the vascular walls in the pancreas. It was strongly suggested that the acute pancreatitis in all three patients was attributable to deposition of amyloid in vascular and pancreatic tissues. Acute pancreatitis is considered to be a rare complication of end-stage amyloidosis associated with RA, and is frequently fatal. It is important to treat RA patients intensively to avoid such deposition of amyloid.
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