期刊
INTERNAL AND EMERGENCY MEDICINE
卷 7, 期 -, 页码 S263-S270出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11739-012-0830-9
关键词
Predictive power; Cardiovascular risk; Biomarkers; Atherosclerosis
Over the past few decades, a number of coronary artery disease (CAD) and cardiovascular disease (CVD) risk factors have been identified. The predictive power of conventional'' risk factors have been validated by observational, prospective and intervention studies. Nevertheless, all attempts to exactly predict the individual risk for CAD have failed, biased by a large number of incorrectly risk-classified subjects. To improve cardiovascular (CV) risk prediction, a large number of genetic and/or non-genetic biomarkers have been discovered and tested against the classical'' risk factors for their power to predict CV risk. Only few of them had a significant improvement over the predictive models. In this paper, the most investigated biomarkers will be discussed and the evidence of their use as predictors of CV will be questioned.
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