期刊
INTENSIVE CARE MEDICINE
卷 38, 期 3, 页码 509-517出版社
SPRINGER
DOI: 10.1007/s00134-012-2482-7
关键词
Nitric oxide; Hypercapnic acidosis; Hypoxic pulmonary vasoconstriction; Exhaled nitric oxide; Cyclic guanosine monophosphate; Pulmonary blood flow
资金
- Swedish Research Council [5315]
- Swedish Heart-Lung Fund
- Tore Nilsson Research Fund, Stockholm, Sweden
- Selander Research Fund, Uppsala, Sweden
- AGA AB, Lidingo, Sweden
- Laerdal Foundation, Stavanger, Norway
- Hedenstierna Laboratory, University Hospital, Uppsala, Sweden
Hypercapnic acidosis often occurs in critically ill patients and during protective mechanical ventilation; however, the effect of hypercapnic acidosis on endogenous nitric oxide (NO) production and hypoxic pulmonary vasoconstriction (HPV) presents conflicting results. The aim of this study is to test the hypothesis that hypercapnic acidosis augments HPV without changing endogenous NO production in both hyperoxic and hypoxic lung regions in pigs. Sixteen healthy anesthetized pigs were separately ventilated with hypoxic gas to the left lower lobe (LLL) and hyperoxic gas to the rest of the lung. Eight pigs received 10% carbon dioxide (CO2) inhalation to both lung regions (hypercapnia group), and eight pigs formed the control group. NO concentration in exhaled air (ENO), nitric oxide synthase (NOS) activity, cyclic guanosine monophosphate (cGMP) in lung tissue, and regional pulmonary blood flow were measured. There were no differences between the groups for ENO, Ca2+-independent or Ca2+-dependent NOS activity, or cGMP in hypoxic or hyperoxic lung regions. Relative perfusion to LLL (Q (LLL)/Q (T)) was reduced similarly in both groups when LLL hypoxia was induced. During the first 90 min of hypercapnia, Q (LLL)/Q (T) increased from 6% (1%) [mean (standard deviation, SD)] to 9% (2%) (p < 0.01), and then decreased to the same level as the control group, where Q (LLL)/Q (T) remained unchanged. Cardiac output increased during hypercapnia (p < 0.01), resulting in increased oxygen delivery (p < 0.01), despite decreased PaO2 (p < 0.01)(.) Hypercapnic acidosis does not potentiate HPV, but rather transiently weakens HPV, and does not affect endogenous NO production in either hypoxic or hyperoxic lung regions.
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