期刊
INTEGRATIVE CANCER THERAPIES
卷 8, 期 4, 页码 329-336出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735409352029
关键词
circadian rhythm; clock gene; cytokine; inflammation
资金
- Arnold School of Public Health and Center for Colorectal Cancer Research, University of South Carolina, Columbia, South Carolina
- US Department of Veterans Affairs, VISN-7, Charleston, South Carolina
- Cancer Training Branch of the National Cancer Institute [K05 CA136975]
- Biostatistics and Epidemiology Branch of the National Institute for Occupational Safety and Health, Centers for Disease Control and Prevcntion, Morgantown, West Virginia [212-2008-M-24052]
Circadian disruption has been linked with inflammation, an established cancer risk factor. Per3 clock gene polymorphisms have also been associated with circadian disruption and with increased cancer risk. Patients completed a questionnaire and provided a blood sample prior to undergoing a colonoscopy (n = 70).Adjusted mean serum cytokine concentrations (IL-6, TNF-alpha, gamma-INF, IL-I ra, IL-I-beta,VEGF) were compared among patients with high and low scores for fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory 11), or sleep disruption (Pittsburgh Sleep Quality Index), or among patients with different Per3 clock gene variants. Poor sleep was associated with elevated VEGF, and fatigue-related reduced activity was associated with elevated TNF-alpha concentrations. Participants with the 4/5 or 5/5 Per3 variable tandem repeat sequence had elevated IL-6 concentrations compared to those with the 4/4 genotype. Biological processes linking circadian disruption with cancer remain to be elucidated. Increased inflammatory cytokine secretion may play a role.
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