期刊
INTEGRATIVE CANCER THERAPIES
卷 7, 期 2, 页码 81-89出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735408319062
关键词
vitamin D; 25-OH vitamin D; 1,25-OH vitamin D; malignancies; vitamin D deficiency; vitamin D status and prognosis of malignancies; melatonin; melanoma; circadian rhythm of light and darkness; prostate cancer
Studies show an important relationship between vitamin D and malignancies, both in prevention and treatment. The extraskeletal actions of vitamin D relevant to oncology include being proapoptotic, antimetastatic, antiangiogenic, antiinflammatory, prodifferentiating, and immunomodulating. Widespread and severe vitamin D deficiencies exist worldwide. Decreased sun exposure, caused by lifestyle changes, as well as fear of skin cancers, is the main cause of these deficiencies. Recommended daily oral intakes, as well as suggested blood levels, are below optimal levels suggested by studies. Improvement in vitamin D status, through lifestyle changes and supplementation, can be of profound benefit regarding the occurrence and mortality of malignancies.
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