期刊
INTEGRATIVE BIOLOGY
卷 10, 期 9, 页码 491-501出版社
OXFORD UNIV PRESS
DOI: 10.1039/c8ib00082d
关键词
-
类别
资金
- National Institutes of Health [OD/NICHD DP2HD083961, 3DP2HD083961-01S1]
- National Science Foundation (CAREER) [CMMI-1254656]
- American Heart Association [13SDG17230047]
- Pew Charitable Trusts [PEW 00026185]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1254656] Funding Source: National Science Foundation
Birth defects are a common occurrence in the United States and worldwide. Currently, evaluation of potential developmental toxicants (i.e., teratogens) relies heavily on animal-based models which do not always adequately mimic human development. In order to address this, researchers are developing in vitro human-based models which utilize human pluripotent stem cells (hPSCs) to assess the teratogenic potential of chemical substances. The field of human developmental toxicity assays includes a variety of platforms including monolayer, micropattern, embryoid body, and 3D organoid cultures. In this review, we will overview the field of human teratogenic assays, detail the most recent advances, and discuss current limitations and future perspectives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据