期刊
INTEGRATIVE BIOLOGY
卷 6, 期 7, 页码 654-661出版社
OXFORD UNIV PRESS
DOI: 10.1039/c4ib00022f
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资金
- NRF - MEST [2013R1A2A2A03016122]
- Ministry of Trade, Industry & Energy, Republic of Korea [20124010203250]
- Basic Science Research Program through the NRF of Korea - Ministry of Education, Science and Technology [2012-022481]
- Bio & Medical Technology Development Program [2011-0019633]
- MEST [2012R1A1A1012853]
We present a novel in vitro breast tumor model to mimic intratumoral phenotypic heterogeneity based on a microfluidic system incorporating ECM scaffolds capable of providing a physiologically relevant tumor microenvironment. To study the regulation of invasive potentials by intratumoral subpopulation conditions, we developed heterogeneous cancer cell subpopulations by co-culturing two breast cancer cell types with distinct phenotypes, specifically, highly invasive and epithelial-like cancer cells. Our results indicate that intratumoral phenotypic heterogeneity acts as an encourager of cancer cell invasion through a 3D matrix depending on the neighboring ECM, with highly invasive cancer cells acting as the 'leader' and epithelial-like cancer cells as the 'follower', therefore enhancing the metastatic potential.
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