期刊
INTEGRATIVE BIOLOGY
卷 4, 期 6, 页码 587-594出版社
OXFORD UNIV PRESS
DOI: 10.1039/c2ib20017a
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类别
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology (MEST) [2011-0001643, 2011K000682 2011-0000331, 2011-0000318, 2011-0001293, 2011-0018905]
In order to successfully utilize stem cells for therapeutic applications in regenerative medicine, efficient differentiation into a specific cell lineage and guidance of axons in a desired direction is crucial. Here, we used aligned multi-walled carbon nanotube (MWCNT) sheets to differentiate human mesenchymal stem cells (hMSCs) into neural cells. Human MSCs present a preferential adhesion to aligned CNT sheets with longitudinal stretch parallel to the CNT orientation direction. Cell elongation was 2-fold higher than the control and most of the cells were aligned on CNT sheets within 51 from the CNT orientation direction. Furthermore, a significant, synergistic enhancement of neural differentiation was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also controlled using nanoscale patterning of CNTs. This CNT sheet provides a new cellular scaffold platform that can regulate morphogenesis and differentiation of stem cells, which could open up a new approach for tissue and stem cell regeneration.
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