期刊
MEDICAL ONCOLOGY
卷 32, 期 8, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-015-0655-2
关键词
Programmed death ligand 1; Renal cell carcinoma; Metastasis; SREBP-1c
类别
资金
- Scientific Research Projects of Shanghai under the Shanghai Science and Technology Commission [14ZR1406300]
- National Natural Science Foundation of China [81472376]
The incidence of kidney cancer has been increasing globally during the past two decades. Renal cell carcinoma (RCC) is the most aggressive subtype of kidney cancer, which usually deteriorates with epithelial-mesenchymal transition (EMT) that facilitates the migration and invasion of cancer cells. Till now, the underlying mechanism remains unclear. In this study, we demonstrated that programmed death ligand 1 (PD-L1/B7-H1/CD274) could induce EMT and enhance RCC cell cancer stemness through up-regulation of SREBP-1c. Furthermore, we found that PD-L1 is up-regulated in human RCC metastases. These results, taken together, provide evidence for a novel mechanism of PD-L1 in RCC progression, suggesting that there is a close relationship between EMT and immune escape signaling pathways in RCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据