期刊
INSECT SCIENCE
卷 15, 期 1, 页码 29-43出版社
WILEY
DOI: 10.1111/j.1744-7917.2008.00185.x
关键词
innate; immunity; Drosophila; genomes; NF-kappa B; signal transduction; JAK-STAT; antimicrobial peptides
类别
资金
- NIGMS NIH HHS [S06 GM008168-270061] Funding Source: Medline
Following in the footsteps of traditional developmental genetics, research over the last 15 years has shown that innate immunity against bacteria and fungi is governed largely by two NF-kappa B signal transduction pathways, Toll and IMD. Antiviral immunity appears to stem from RNA interference, whereas resistance against parasitoids is conferred by Toll signaling. The identification of these post-transcriptional regulatory mechanisms and the annotation of most Drosophila immunity genes have derived from functional genomic studies using model pathogens, intact animals and cell lines. The D. melanogaster host has thus provided the core information that can be used to study responses to natural microbial and metazoan pathogens as they become identified, as well as to test ideas of selection and evolutionary change. These analyses are of general importance to understanding mechanisms of other insect host-pathogen interactions and determinants of variation in host resistance.
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