期刊
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 42, 期 2, 页码 126-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2011.11.005
关键词
Aedes aegypti; Dengue virus; Beauveria bassiana; Innate immunity
资金
- NIH [AI080161-01A1, R01AI078997-02, R21AI090188-02]
- National Institutes of Health/National Institute of Allergy and Infectious Disease [R01AI078997-02, R21AI090188-02]
- Johns Hopkins School of Public Health Faculty Innovation
- Johns Hopkins Malaria Research Institute
- Johns Hopkins Diversity Research Internship Program
- NRSA [F31 AI080161-01A1]
- American Society for Microbiology
Here we investigated the effect of Beauveria bassiana infection on the survival of Aedes aegypti mosquitoes and the modulation of their susceptibility to dengue virus infection. Application of B. bassiana caused a reduction in the life span of A. aegypti and hindered dengue virus replication in the mosquito midgut. Fungus infection induced the expression a variety anti-microbial and dengue virus restriction factor genes. Transient reverse genetic analyses showed that the JAK-STAT pathway is implicated anti-fungal defense of Aedes mosquitoes. Our data suggest that this B. bassiana-mediated anti-dengue activity is likely to be at least partly indirectly mediated through the activation of the mosquito's anti-dengue Toll and JAK-STAT pathways. (C) 2011 Elsevier Ltd. All rights reserved.
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