Synthesis, structural characterization, and preliminary cancer cell study results for poly(amine esters) derived from triphenyl-group VA organometallics and norfloxacin

Poly(amine esters) are rapidly formed employing the interfacial condensation of group VA triphenylmetal dihalides with the antibacterial agent norfloxacin in moderate yield and low to high polymers with respect to average chain length. Infrared spectroscopy shows the formation of M-oxygen and M-N bonds. The products are largely bridging structures about the metal atom. Proton NMR and MALDI MS results are consistent with the formation of the poly(amine esters). All of the polymers show good activity against several of the tested cancer cell lines. (C) 2014 Elsevier B.V. All rights reserved.