Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, H-1, C-13, Sn-119 NMR, Sn-119m Mossbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity. (C) 2014 Elsevier B.V. All rights reserved.