期刊
INORGANICA CHIMICA ACTA
卷 385, 期 -, 页码 81-93出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2011.12.038
关键词
Copper(II) complexes; DNA binding; Protein binding; Antioxidant; Cytotoxicity
资金
- Council of Scientific and Industrial Research, New Delhi, India [01(2216)/08/EMR-II, 21(0745)/09/EMR-II]
Two new copper(II) complexes have been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde( 2'-hydroxybenzoyl) hydrazone (H2L) (1) with CuCl2 center dot 2H(2)O or Cu(NO3)(2)center dot 3H(2)O, in order to obtain a clear picture on the role of counter ion in the biological properties of the complexes so obtained. Single-crystal X-ray diffraction studies revealed that both the complexes [CuCl(HL)(H2O)]center dot CH3OH (2) and [Cu(HL)(CH3OH)(2)]NO3 (3) have square pyramidal geometry with the ligand coordinating through uninegative tridentate ONO fashion. The UV-Vis and fluorescence spectroscopy experimental evidences strongly suggested that the ligand and the two Cu(II) complexes could interact with calf thymus DNA (CT-DNA) through intercalation. The interactions of the compounds to bovine serum albumin (BSA) were investigated by UV-Vis, fluorescence and synchronous fluorescence spectra. The results indicated that all the three compounds could quench the intrinsic fluorescence of BSA in a static quenching way. Investigations of antioxidative properties showed that all the compounds have strong radical scavenging properties. Cytotoxic studies showed that the two copper(II) complexes exhibited effective cytotoxic activity against HeLa cancer cells. Overall, the complex 3 has exhibited better biological activity than that of the complex 2 and the ligand. (C) 2011 Elsevier B.V. All rights reserved.
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