Synthesis, characterization and cytotoxic effect of ring-substituted and ansa-bridged vanadocene complexes

The cytotoxic effect of vanadocene dichloride (Cp2VCl2, 1) and its ring-substituted, (eta(5)-C5H4Me)(2)VCl2 (2), (eta(5)-C5Me5)(2)VCl2 (3), (eta 5-C5H4R)(2)VCl2 (4: R = MeOCH2CH2-, 5: R = 2-MeOC6H4CH2-, 6: R = 4-MeOC6H4CH2-) and ansa-bridged analogs Me2C(eta(5)-C5H4)(2)VCl2 (7) and Me4C2(eta(5)-C5H4)(2)VCl2 (8) was investigated. Synthesis of two new methoxy-functionalized compounds (4 and 5) is described. They were characterized by spectroscopic methods and X-ray diffraction analysis. The cytotoxicity studies were performed with leukemic cells MOLT-4. (C) 2011 Elsevier B. V. All rights reserved.