期刊
MEDICAL IMAGE ANALYSIS
卷 26, 期 1, 页码 159-172出版社
ELSEVIER
DOI: 10.1016/j.media.2015.08.012
关键词
40 flow; PC-MRI; Pressure differences estimation; Work-energy equation; Aortic flow
类别
资金
- Department of Health, via the NIHR comprehensive Biomedical Research Centre
- King's College Hospital NHS Foundation Trust
- Wellcome Trust-EPSRC Centre of Excellence in Medical Engineering [WT 088641/Z/09/Z]
- BHF New Horizons program [NH/11/5/29058]
- European Research Council under the European UnionOs Seventh Framework Programme (FP) / ERC Grant [307532]
- Wellcome Trust [099973/Z/12/Z]
- Royal Society [099973/Z/12/Z]
- KCL
- British Heart Foundation [NH/11/5/29058] Funding Source: researchfish
- Wellcome Trust [099973/Z/12/Z] Funding Source: Wellcome Trust
Pressure difference is an accepted clinical biomarker for cardiovascular disease conditions such as aortic coarctation. Currently, measurements of pressure differences in the clinic rely on invasive techniques (catheterization), prompting development of non-invasive estimates based on blood flow. In this work, we propose a non-invasive estimation procedure deriving pressure difference from the work-energy equation for a Newtonian fluid. Spatial and temporal convergence is demonstrated on in silico Phase Contrast Magnetic Resonance Image (PC-MRI) phantoms with steady and transient flow fields. The method is also tested on an image dataset generated in silico from a 3D patient-specific Computational Fluid Dynamics (CFD) simulation and finally evaluated on a cohort of 9 subjects. The performance is compared to existing approaches based on steady and unsteady Bernoulli formulations as well as the pressure Poisson equation. The new technique shows good accuracy, robustness to noise, and robustness to the image segmentation process, illustrating the potential of this approach for non-invasive pressure difference estimation. (C) 2015 The Authors. Published by Elsevier B.V.
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