期刊
MEDICAL HYPOTHESES
卷 85, 期 2, 页码 127-129出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2015.04.009
关键词
-
Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据