期刊
INORGANICA CHIMICA ACTA
卷 362, 期 1, 页码 125-135出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2008.03.092
关键词
Rheumatoid arthritis; Copper(II); Speciation; Potentiometry; Spectroscopy; Bio-modelling; Bio-distribution
资金
- National Research Foundation (NRF)
- Canon Collins Trust
- Council of the University of Cape Town
Copper complexes of N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine and bis-(N,N-dimethylethyl)-2,6- pyridinedicarboxamide have been studied by glass electrode potentiometry, NMR, UV and IR spectroscopy as potential anti-inflammatory agents for the alleviation of inflammation associated with rheumatoid arthritis. The protonation and formation constants with Cu(II), Zn(II) and Ca(II), determined at 25 degrees C and an ionic strength of 0.15 mol dm (3) were used to calculate the copper plasma mobilizing index of the ligands. Spectroscopic studies suggested that metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal distorted copper complexes. Bio-distribution and dermal absorption studies showed the complexes to have relatively long biological half-lives with 50% of the injected dose remaining in the body 24 h after administration. (c) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据