期刊
INORGANICA CHIMICA ACTA
卷 362, 期 8, 页码 2595-2602出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2008.11.030
关键词
Bis(pyrazolyl)acetic acid compounds; Cytotoxicity; Pseudo first-order; Substitution; L-cysteine
资金
- Southern & Eastern African Network of Analytical Chemists (SEANAC)
A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R(2)bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R(2)bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5-R(2)bpza)] Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R(2)bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N boolean AND N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with L-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities. (C) 2008 Elsevier B.V. All rights reserved.
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