DNA interaction and in-vitro antibacterial studies of fluoroquinolone based platinum(II) complexes

A series of square planar complexes of the type [Pt(FQ)(2)] (where FQ is deprotonated fluoroquinolone family drug) has been synthesized and characterized. The synthesized complexes have been checked for their in-vitro antimicrobial activity against two Gram((+ve)) and three Gram((-ve)) bacterial species. Intrinsic binding constant (K-b) and mode of binding of complexes toward Herring Sperm DNA (HS DNA) have been determined using absorption titration and viscosity measurement, suggesting the partial intercalative mode of binding. Cleavage ability of complexes has been checked using gel electrophoresis technique and the result shows that the synthesized complexes cleave the DNA more efficiently compared to their respective fluoroquinolones and metal salt. (C) 2011 Elsevier B.V. All rights reserved.