Synthesis, crystal structures and biological activities of 2-acetylpyridine N(4)-cyclohexylthiosemicarbazone and its manganese (II) and nickel (II) complexes

2-Acetylpyridine N(4)-cyclohexylthiosemicarbazone (HL) and its manganese(11) and nickel(11) complexes formulated as [Mn(L)(2)] (1) and [Ni(L)(2)] (2) have been synthesized and characterized by elemental analysis, infrared spectra, mass spectra, and single-crystal X-ray diffraction studies. In the two complexes, the coordination polyhedron approaches an octahedron, where the two ligands coordinate to the metal via the pyridine nitrogen atom and the nitrogen and sulfur donors of the thiosemicarbazide moiety. Biological studies, carried out in vitro against selected bacteria and K562 leukaemia cell line, respectively, have shown that the free ligand and its complexes exhibited distinct differences in the biological activities. (C) 2010 Elsevier B.V. All rights reserved.