期刊
INORGANIC CHEMISTRY
卷 53, 期 2, 页码 727-736出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic401529u
关键词
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资金
- Technology Strategy Board
- EPSRC
- Ministry of Education, Brunei Darussalam
Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
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