Homochiral Metal-Organic Frameworks with Enantiopure Proline Units for the Catalytic Synthesis of β-Lactams

Two enantiopure organic ligands integrating flexible proline units and rigid isophthalate units have been rationally designed and employed for the construction of four homochiral porous metal-organic frameworks (MOFs), respectively. One pair of these MOFs is used as heterogeneous catalysts to construct beta-lactam derivatives by oxidative coupling reactions.