期刊
INORGANIC CHEMISTRY
卷 53, 期 13, 页码 6491-6493出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic500732z
关键词
-
资金
- NIH Grant from the National Institute of General Medical Sciences [GM065519]
- [1S10RR13886-01]
We report the synthesis and photophysical properties of ZBR4 and ZR1, two resorufin-based ditopic probes for mobile zinc. Upon binding Zn2+, the sensors display 14- and 41-fold enhancements of their red fluorescence emission, respectively. In contrast to ZR1 and other members of the ZBR family, which accumulate in the endoplasmic reticulum, ZBR4 spontaneously localizes to the mitochondria of He La cells. The modular approach in designing the constructs facilitates a homologation strategy aimed at tuning the zinc-binding and intracellular targeting properties of future probes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据