期刊
INORGANIC CHEMISTRY
卷 53, 期 11, 页码 5724-5737出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic500483p
关键词
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资金
- UNLP
- UNCAUS
- CONICET [PIP 1529]
- CICPBA
- ANPCyT, Argentina [PME06 2804, PICT06 2315]
- [SAF2010-16198]
A new Cu(II) complex with the antihypertensive drug telmisartan, [Cu(8)Tlm(16)]center dot 24H(2)O (CuTlm), was synthesized and characterized by elemental analysis and electronic, FTIR, Raman and electron paramagnetic resonance spectroscopy. The crystal structure (at 120 K) was solved by X-ray diffraction methods. The octanuclear complex is a hydrate of but otherwise isostructural to the previously reported [Cu(8)Tlm(16)] complex. [Cu(8)Tlm(16)]center dot 24H(2)O crystallizes in the tetragonal P4/ncc space group with a = b = 47.335(1), c = 30.894(3) angstrom, Z = 4 molecules per unit cell giving a macrocyclic ring with a double helical structure. The Cu(II) ions are in a distorted bipyramidal environment with a somewhat twisted square basis, cis-coordinated at their core N2O2 basis to two carboxylate oxygen and two terminal benzimidazole nitrogen atoms. Cu(8)Tlm(16) has a toroidal-like shape with a hydrophobic nanometer hole, and their crystal packing defines nanochannels that extend along the crystal c-axis. Several biological activities of the complex and the parent ligand were examined in vitro. The antioxidant measurements indicate that the complex behaves as a superoxide dismutase mimic with improved superoxide scavenger power as compared with native sartan. The capacity of telmisartan and its copper complex to expand human mesangial cells (previously contracted by angiotensin II treatment) is similar to each other. The antihypertensive effect of the compounds is attributed to the strongest binding affinity to angiotensin II type 1 receptor and not to the antioxidant effects. The cytotoxic activity of the complex and that of its components was determined against lung cancer cell line A549 and three prostate cancer cell lines (LNCaP, PC-3, and DU 145). The complex displays some inhibitory effect on the A549 line and a high viability decrease on the LNCaP (androgen-sensitive) line. From flow cytometric analysis, an apoptotic mechanism was established for the latter cell line. Telmisartan and CuTlm show antibacterial and antifungal activities in various strains, and CuTlm displays improved activity against the Staphylococcus aureus strain as compared with unbounded copper(II).
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