期刊
INORGANIC CHEMISTRY
卷 53, 期 15, 页码 7806-7808出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic5012583
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资金
- Ministerio de Economia y Competitividad [SAF2012-34424]
- Beneficentia Stiftung (Vaduz, Liechtestein)
- COST Action [CM1105]
The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the Pt-II center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl2(dma)(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin.
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