期刊
INORGANIC CHEMISTRY
卷 53, 期 4, 页码 1880-1899出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic401607z
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资金
- NCI NIH HHS [R00 CA172695, P30 CA008748, R01 CA176671, R01 CA172546] Funding Source: Medline
Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: Cu-64-ATSM, Ga-68-DOTATOC, Zr-89-transferrin, Tc-99m-sestamibi, and Tc-99m-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.
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