期刊
INORGANIC CHEMISTRY
卷 53, 期 4, 页码 1900-1915出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic401587r
关键词
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资金
- U.S. National Cancer Institute [R01-CA126642]
Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO(2), and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
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