期刊
INORGANIC CHEMISTRY
卷 52, 期 14, 页码 7968-7979出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic4005104
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资金
- Department of Science and Technology, New Delhi, India [SR/S2/RJN-11/2008]
- OSDD unit of the Council of Scientific & Industrial Research, New Delhi, India [OSDD/HCP0001/12FYP/2012-13/Fin/2455]
- Nigerian Government
- U.S. Department of Energy, Office of Basic Energy Science [DE-FG02-06ER15799]
A versatile class of heme monoxygenases involved in many vital functions for human health are the cytochromes P450, which react via a high-valent iron(IV) oxo heme cation radical species called Compound I. One of the key reactions catalyzed by these enzymes is C=C epoxidation of substrates. We report here a systematic study into the intrinsic chemical properties of substrate and oxidant that affect reactivity patterns. To this end, we investigated the effect of styrene and para-substituted styrene epoxidation by Compound I models with either an anionic (chloride) or neutral (acetonitrile) axial ligand. We show, for the first time, that the activation enthalpy of the reaction is determined by the ionization potential of the substrate, the electron affinity of the oxidant, and the strength of the newly formed C-O bond (approximated by the bond dissociation energy, BDEOH). We have set up a new valence bond model that enables us to generalize substrate epoxidation reactions by iron(IV)-oxo porphyrin cation-radical oxidants and make predictions of rate constants and reactivities. We show here that electron-withdrawing substituents lead to early transition states, whereas electron-donating groups on the olefin substrate give late transition states. This affects the barrier heights in such a way that electron-withdrawing substituents correlate the barrier height with BDEOH, while the electron affinity of the oxidant is proportional to the barrier height for substrates with electron-donating substituents.
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