期刊
INORGANIC CHEMISTRY
卷 52, 期 10, 页码 5702-5713出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic3022062
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资金
- Natural Science Foundation of China [21173099, 20973078]
- Major State Basis Research Development Program [2013CB 834801]
- Natural Science Foundation of Jiangsu Provincial Department of Education [SCZ1212400003]
- special funding to basic scientific research projects for Central Colleges
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Foundation of State Key Laboratory of Theoretical and Computational Chemistry, Jilin University
A two-photon fluorescent probe has become a critical tool in biology and medicine owing to its capability of imaging intact tissue for a long period of time, such as in two-photon fluorescence microscopy (TPM). In this context, a series of Salen-based zinc-ion bioimaging reagents that were designed based on an intramolecular charge-transfer mechanism were studied through the quantum-chemical method. The increase of one-photon absorption and fluorescence emission wavelength and the reduction of the oscillator strength upon coordination with a zinc ion reveal that they are fluorescent bioimaging reagents used for ratiometric detection. When the Salen ligand is incorporated with Zn2+, the value of the two-photon absorption (TPA) cross-section (delta(max)) will decrease, and most of the ligands and complexes exhibit a TPA peak in the near-infrared spectral region. That is, a substituent at the end of the ligand can influence the luminescence property, besides increasing solubility. In addition, the effect of an end-substituted position on the TPA property was considered, such as ortho and meta substitution. The detailed investigations will provide a theoretical basis to synthesize zinc-ion-responsive two-photon fluorescent bioimaging reagents as powerful tools for TPM and biological detection in vivo.
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