期刊
INORGANIC CHEMISTRY
卷 51, 期 22, 页码 12521-12526出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic301959z
关键词
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资金
- National Natural Science Foundation of China [21071043]
Up to now, bismuth(III) complexes with thiosemicarbazones have been comparatively rare. Few in vivo biological studies have been carried out in comparison to the plentiful in vitro data. Here, an interesting nine-coordinated bismuth(III) complex, [Bi(H2L)(NO3)(2)]NO3 [1; H2L = 2,6-diacetylpyridine bis(N-4-methylthiosemicarbazone)], has been synthesized and structurally characterized. The analytical data reveal the formation of 1:1 (metal/ligand) stoichiometry. In vitro biological studies have indicated that the bismuth complex 1 has shown much higher antibacterial and anticancer activities than its parent ligand, especially with MIC = 10.66 mu M against Bacillus cereus and Salmonella typhimurium and IC50 = 26.8 mu M against K562 leukemia cells, respectively. More importantly, it also evidently inhibits H22 xenograft tumor growth on tumor-bearing mice (10 mg/kg; inhibitory rate = 61.6%). These results indicate that coordination to bismuth(III) might be an interesting strategy in the discovery of new anticancer drug candidates.
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