期刊
INORGANIC CHEMISTRY
卷 51, 期 23, 页码 12697-12706出版社
AMER CHEMICAL SOC
DOI: 10.1021/ic301310q
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [22890200, 19659026, 22390005, 22659005, 24659058]
- MEXT
- Grants-in-Aid for Scientific Research [24890256, 22659005, 22890200, 24659058] Funding Source: KAKEN
Cyclometalated iridium(III) complexes have received considerable attention and are important candidates for use as luminescent probes for cellular imaging because of their potential photophysical properties. We previously reported that fac-Ir(atpy)(3) 4 (atpy = 2-(5'-amino-4'-tolyl)pyridine) containing three amino groups at the 5'-position of the atpy ligand shows a maximum red emission (at around 600 nm) under neutral and basic conditions and a green emission (at 531 nm) at acidic pH (pH 3-4). In this Article, we report on the design and synthesis of a new pH-sensitive cyclometalated Ir(III) complex containing a 2-(5'-N,N-diethylamino-4'-tolyl)pyridine (deatpy) ligand, fac-Ir(deatpy)(3) 5. The complex exhibits a considerable change in emission intensity between neutral and slightly acidic pH (pH 6.5-7.4). Luminescence microscopic studies using HeLa-S3 cells indicate that 5 can be used to selectively stain lysosome, an acidic organelle in cells. Moreover, complex 5 is capable of generating singlet oxygen in a pH-dependent manner and inducing the death of HeLa-S3 cells upon photoirradiation at 377 or 470 nm.
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