4.7 Article

Kinetic Inertness of the Mn2+ Complexes Formed with AAZTA and Some Open-Chain EDTA Derivatives

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INORGANIC CHEMISTRY
卷 51, 期 19, 页码 10065-10067

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AMER CHEMICAL SOC
DOI: 10.1021/ic300832e

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  1. Hungarian Scientific Research Foundation [OTKA PD-83253, OTKA K-84291]
  2. Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences

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The results of systematic equilibrium, kinetic, and relaxometric investigations carried out on the Mn2+ complexes of open-chain and AAZTA ligands indicate that the [Mn(CDTA)](2-) complex has satisfactorily high kinetic inertness (t(1/2) = 12 h at pH = 7.4), which, in turn, may allow its use as a contrast agent in the field of magnetic resonance imaging (as a replacement for Gd3+-based agents).

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