期刊
MEDIATORS OF INFLAMMATION
卷 2015, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2015/807976
关键词
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资金
- National Natural Science Foundation of China [81370166]
- Zhejiang Provincial Natural Science Foundation of China [LY13H090014]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201327689]
- Scientific Innovation Team Project of Ningbo [2011B82014]
- Social Development Program of Ningbo [2013C50054]
- Scientific Research Foundation of Graduate School of Ningbo University [G14036]
- K. C. Wong Magna Fund in Ningbo University
Interleukin-(IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36 gamma, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.
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