期刊
INNATE IMMUNITY
卷 19, 期 3, 页码 227-241出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425912460708
关键词
Antibiotics; antimicrobial peptides; cathelicidins; DEFB1; defensins; elicitor; innate immunity; keratinocyte; LL-37; TLR
资金
- Fondos Sectoriales de Ciencia Basica SEP-CONACYT Mexico [CB-2008-01-105813]
Antimicrobial peptides or host defense peptides are fundamental components of human innate immunity. Recent and growing evidence suggests they have a role in a broad range of diseases, including cancer, allergies and susceptibility to infection, including HIV/AIDS. Antimicrobial peptide elicitors (APEs) are physical, biological or chemical agents that boost human antimicrobial peptide expression. The current knowledge of APEs and their potential use in the treatment of human infectious diseases are reviewed, and a classification system for APEs is proposed. The efficient use of APEs in clinical practice could mark the beginning of the urgently needed post-antibiotic era, but further trials assessing their efficacy and safety are required.
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