期刊
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
卷 39, 期 -, 页码 S83-S90出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0020-1383(08)70019-6
关键词
Bone morphogenetic proteins; BMP-7; OP-1; Non-unions; Tibia; Grafting; Multicenter; Prospective; Case series; bmpusergroup.co.uk
The effective treatment of the often debilitating, longlasting and large-asset-consuming complication of fracture non-unions has been in the centre of scientific interest the last decades. The use of alternative bone substitutes to the gold standard of autologous graft includes the osteoinductive molecules named bone morphogenetic proteins (BMPs). A multicenter registry and database (bmpusergroup.co.uk) focused on the application of BMP-7/OP-1 was created in December 2005. We present the preliminary results, using the prospective case-series of aseptic tibial. non-unions as an example. Sixty-eight patients fulfilled the inclusion criteria for this observational study, with a minimum follow-up of 12 months. The median duration of tibial. non-union prior to BMP-7 application was 23 months (range 9-317 mo). Patients had undergone a median of 2 (range 0-11) revision procedures prior to the administration of BMP-7. In 41% the application of BMP-7 was combined with revision of the fixation at the non-union site. Non-union heating was verified in 61 (89.7%) in a median period of 6.5 months (range 3-15 mo). No adverse events or complications were associated with BMP-7 application. The safety and efficacy of BMP-7 was verified in our case series, and was comparable to the existing evidence. The establishment of multicenter networks and the systematic and long-term follow-up of these patients are expected to provide further information and significantly improve our understanding of this promising osteoinductive bone substitute. (C) 2008 Elsevier Ltd. All rights reserved.
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