期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 146, 期 -, 页码 53-64出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2015.04.001
关键词
Alzheimer's disease; Parkinson's disease; Poly(ADP-ribose)polymerase; Mitochondria
DNA damage is the prime activator of the enzyme poly(ADP-ribose)polymerase1 (PARP-1) whose over-activation has been proven to be associated with the pathogenesis of numerous central nervous system disorders, such as ischemia, neuroinflammation, and neurodegenerative diseases. Under oxidative stress conditions PARP-1 activity increases, leading to an accumulation of ADP-ribose polymers and NAD(+) depletion, that induces energy crisis and finally cell death. This review aims to explain the contribution of PARP-1 in neurodegenerative diseases, focusing on Alzheimer's and Parkinson's disease, to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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