期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 150, 期 -, 页码 46-54出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2015.08.006
关键词
Haemostasis; Coagulation; Platelets; Aging
资金
- CONICYT REGIONAL/GORE [MAULE/CEAP/R09I2001]
- Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES)
- Fondecyt, Chile [1130216]
- FONDECYT [11140142]
Life expectancy has increased in many countries as a result the world's population is aging. The projections indicate that the proportion of the elderly in a few decades will increase significantly. Aging carries with it a series of physiological changes; one of them is an imbalance in the hemostatic system. Thus the levels or activity of various proteins involved, such as most coagulation factors, natural anticoagulants and the fibrinolytic system are altered so that the hemostatic balance leans toward thrombosis. Also, platelet activity suggests a state of abnormal activation (P-selectin, beta thromboglobulin and platelet factor). In this review we will systematically examine the alterations in the hemostatic components that occur during aging. Therefore, understanding these hemostatic changes could contribute to developing strategies for the proper management of health in old age. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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