期刊
INFLUENZA AND OTHER RESPIRATORY VIRUSES
卷 7, 期 -, 页码 72-75出版社
WILEY-BLACKWELL
DOI: 10.1111/irv.12084
关键词
Immunocompromised; influenza; meta-analysis; systematic review; vaccination
资金
- WHO
- East Midlands NHS Healthcare Workforce Deanery, UK
- University of Nottingham
- Global Influenza Programme, World Health Organization
- Health Protection Agency, UK
- National Institutes of Health Research (NIHR) [PDF-2012-05-305] Funding Source: National Institutes of Health Research (NIHR)
- National Institute for Health Research [ACF-2008-18-010, PDF-2012-05-305, CL-2012-18-005, ACF-2009-21-030, CL-2009-18-014] Funding Source: researchfish
Vaccination of immunocompromised patients is recommended in many national guidelines to protect against severe or complicated influenza infection. However, due to uncertainties over the evidence base, implementation is frequently patchy and dependent on individual clinical discretion. We conducted a systematic review and meta-analysis to assess the evidence for influenza vaccination in this patient group. Healthcare databases and grey literature were searched and screened for eligibility. Data extraction and assessments of risk of bias were undertaken in duplicate, and results were synthesised narratively and using meta-analysis where possible. Our data show that whilst the serological response following vaccination of immunocompromised patients is less vigorous than in healthy controls, clinical protection is still meaningful, with only mild variation in adverse events between aetiological groups. Although we encountered significant clinical and statistical heterogeneity in many of our meta-analyses, we advocate that immunocompromised patients should be targeted for influenza vaccination.
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