相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
Malin E. V. Johansson et al.
GUT (2014)
IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia
Douglas J. Kominsky et al.
JOURNAL OF IMMUNOLOGY (2014)
Inflammatory bowel disease: Pathogenesis
Yi-Zhen Zhang et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation
Bo Liu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins
Ana M. Rodriguez-Pineiro et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution
Jessica M. Holmen Larsson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches
Anna Ermund et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Transepithelial antigen delivery in the small intestine: different paths, different outcomes
Kathryn A. Knoop et al.
CURRENT OPINION IN GASTROENTEROLOGY (2013)
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
Khushbu K. Patel et al.
EMBO JOURNAL (2013)
IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells
Sumaira Z. Hasnain et al.
GASTROENTEROLOGY (2013)
Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon
Joep Grootjans et al.
GUT (2013)
IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis
Christopher J. Moran et al.
INFLAMMATORY BOWEL DISEASES (2013)
Site-specific O-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by the Porphyromonas gingivalis Secreted Cysteine Protease (RgpB)
Sjoerd van der Post et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains
Malin Backstrom et al.
MOLECULAR BIOTECHNOLOGY (2013)
The gastrointestinal mucus system in health and disease
Malin E. V. Johansson et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)
Dynamic Changes in Mucus Thickness and Ion Secretion during Citrobacter rodentium Infection and Clearance
Jenny K. Gustafsson et al.
PLOS ONE (2013)
Negative feedback by IRE1β optimizes mucin production in goblet cells
Akio Tsuru et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Meimei Shan et al.
SCIENCE (2013)
Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice
Frederic A. Carvalho et al.
CELL HOST & MICROBE (2012)
Inflamed gut mucosa: downstream of interleukin-10
Gregor Paul et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2012)
ZG16p, an animal homolog of β-prism fold plant lectins, interacts with heparan sulfate proteoglycans in pancreatic zymogen granules
Kaori Kumazawa-Inoue et al.
GLYCOBIOLOGY (2012)
Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system
Hiroaki Tateno et al.
GLYCOBIOLOGY (2012)
Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family
Eric P. Bennett et al.
GLYCOBIOLOGY (2012)
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype
Jenny K. Gustafsson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Mucins in inflammatory bowel diseases and colorectal cancer
Yong H. Sheng et al.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2012)
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
Jeremiah R. McDole et al.
NATURE (2012)
Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins
Malin E. V. Johansson
PLOS ONE (2012)
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin
Daniel Ambort et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Defective IL10 Signaling Defi ning a Subgroup of Patients With Inflammatory Bowel Disease
Bernadette Begue et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2011)
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
J. Petersson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)
The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
Benoit Chassaing et al.
GASTROENTEROLOGY (2011)
Altered O-glycosylation Profile of MUC2 Mucin Occurs in Active Ulcerative Colitis and Is Associated with Increased Inflammation
Jessica M. Holmen Larsson et al.
INFLAMMATORY BOWEL DISEASES (2011)
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice
Jianxin Fu et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Shipra Vaishnava et al.
SCIENCE (2011)
ER stress and the unfolded protein response in intestinal inflammation
Michael A. McGuckin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)
Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection
Sumaira Z. Hasnain et al.
GASTROENTEROLOGY (2010)
Sulfation of Colonic Mucins by N-Acetylglucosamine 6-O-Sulfotransferase-2 and Its Protective Function in Experimental Colitis in Mice
Yuki Tobisawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
Kirk S. B. Bergstrom et al.
PLOS PATHOGENS (2010)
Immune adaptations that maintain homeostasis with the intestinal microbiota
Lora V. Hooper et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
Laurens G. van der Flier et al.
ANNUAL REVIEW OF PHYSIOLOGY (2009)
A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn
Jessica M. Holmen Larsson et al.
GLYCOBIOLOGY (2009)
Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse
P. A. Dawson et al.
GUT (2009)
Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein
Malin E. V. Johansson et al.
JOURNAL OF PROTEOME RESEARCH (2009)
MECHANISMS OF DISEASE Inflammatory Bowel Disease
Clara Abraham et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Erik-Oliver Glocker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
Sung-Woo Park et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis
Daniel Laubitz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
Arthur Kaser et al.
CELL (2008)
Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease
Hirornasa Takaishi et al.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2008)
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
Maria van der Sluis et al.
LABORATORY INVESTIGATION (2008)
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Ken Cadwell et al.
NATURE (2008)
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Andre Franke et al.
NATURE GENETICS (2008)
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Malin E. V. Johansson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
Chad K. Heazlewood et al.
PLOS MEDICINE (2008)
Gel-forming mucins appeared early in metazoan evolution
Tiange Lang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer
Marie-Elisabeth Forgue-Lafitte et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota
Alexander Swidsinski et al.
INFLAMMATORY BOWEL DISEASES (2007)
Unravelling the pathogenesis of inflammatory bowel disease
R. J. Xavier et al.
NATURE (2007)
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans
Guangyu An et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Muc2-deficient mice spontaneously develop colitis, indicating that Muc2 is critical for colonic protection
Maria Van der Sluis et al.
GASTROENTEROLOGY (2006)
Bacterial population analysis of human colon and terminal ileum biopsies with 16S rRNA-based fluorescent probes: Commensal bacteria live in suspension and have no direct contact with epithelial cells
LA van der Waaij et al.
INFLAMMATORY BOWEL DISEASES (2005)
Host-bacterial mutualism in the human intestine
F Bäckhed et al.
SCIENCE (2005)
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
JL Sonnenburg et al.
SCIENCE (2005)
RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
D Artis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Immune-mediated alteration in gut physiology and its role in host defence in nematode infection
WI Khan et al.
PARASITE IMMUNOLOGY (2004)
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal α-defensin expression
J Wehkamp et al.
GUT (2004)
Interleukin 10-deficient mice exhibit defective colonic Muc2 synthesis before and after induction of colitis by commensal bacteria
NMJ Schwerbrock et al.
INFLAMMATORY BOWEL DISEASES (2004)
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment
K Godl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Colorectal cancer in mice genetically deficient in the mucin Muc2
A Velcich et al.
SCIENCE (2002)