期刊
INFLAMMATORY BOWEL DISEASES
卷 16, 期 10, 页码 1808-1813出版社
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21248
关键词
Th17; IL-17; IL-23; IL-21; IBD
资金
- Fondazione Umberto di Mario, Rome
- Broad Medical Research Program Foundation [IBD-0154R]
- Giuliani SpA, Milan, Italy
Gut inflammation occurring in patients with Crohn's disease and patients with ulcerative colitis has been traditionally associated with an exaggerated Th1 or Th2 cell response, respectively. However, recent studies have shown that in both inflammatory bowel diseases (IBD) there is also enhanced synthesis of cytokines made by a distinct subset of T helper cells, termed Th17 cells. The discovery that this new T-cell subset drives immune-mediated pathology in the gut, and that interleukin (IL)-23 amplifies Th17 cell responses and gut inflammation, has contributed to elucidate new pathways of tissue damage as well as to open new avenues for development of therapeutic strategies in IBD. Nonetheless, it has been recently shown that Th17-related cytokines, such as IL-17A and IL-22, can exert protective rather than detrimental effects in the gut. We here review the available data regarding the role of Th17 cells and IL-23 in chronic intestinal inflammation. (Inflamm Bowel Dis 2010; 16: 1808-1813)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据