期刊
INFLAMMATORY BOWEL DISEASES
卷 15, 期 3, 页码 335-340出版社
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.20768
关键词
ulcerative colitis; pouchitis; butyrate oxidation
Background: Healthy colonic mucosa uses butyrate as the major energy source. In ulcerative colitis (UC) butyrate oxidation has been shown to be disturbed, but it remains unclear whether this is a primary defect. The aim of this study was to measure mucosal butyrate oxidation in UC (involved and noninvolved colon) and in pouchitis and to study the relationship with endoscopic as well as histological disease activity. Methods: Butyrate oxidation was measured in 73 UC patients, 22 pouchitis patients, and 112 controls (95 colon, 17 ileum) by incu-bating biopsies with 1 mM C-14-labeled Na-butyrate and measuring the released (CO2)-C-14. Results: Compared with that in normal colon, butyrate oxidation was significantly impaired in endoscopically active but not in quiescent disease Or uninvolved colon segments. The severity of the metabolic defect was related to histological disease activity and decreased epithelial cell height. In active pouchitis, butyrate oxidation was significantly decreased compared with that in normal ileum and excluded pouches without inflammation. The histological pouchitis score correlated significantly with butyrate oxidation. Conclusions : Active UC and pouchitis show the same inflammation-related metabolic defect. Our data suggest that the defect is a consequence of inflammation and that pouchitis is metabolically similar to active UC.
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