期刊
INFLAMMATORY BOWEL DISEASES
卷 15, 期 7, 页码 1044-1048出版社
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.20858
关键词
cyclosporine; steroid-refractory; ulcerative colitis
Background: Cyclosporine is considered a safe and effective treatment of severe steroid-refractory ulcerative colitis (UC). However, few data Lire available concerning its safety profile in pregnant I women. We report here the experience of 5 GETAID centers. Methods: In a retrospective study data on patients with severe UC treated with cyclosporine during pregnancy were extracted from medical records of consecutive patients treated between 2001 and 2007. Results: Eight patients (median age 30.5 years old) were identified. At the time of flare-up the median duration of pregnancy was 11.5 weeks of gestation (range 4-25). Seven patients had pancolitis. All patients had more than 3 commonly used clinical and biological severity criteria. Three patients had severe endoscopic lesions and 5 patients had not. All patients received intravenous corticosteroids for at least 7 days before introduction of cyclosporine. Two patients received azathioprine during treatment with cyclosporine. No severe infections or other complications due to treatment were observed. Treatment was effective in 7/8 patients. One patient received infliximab, due to cyclosporine therapy failure with a good outcome. No colectomy was performed during pregnancy. Seven pregnancies were conducted to term, but I in Utero death occurred due to maternal absence of S-protein. Two newborns were premature, including I case of hypotrophy. No malformations were observed. Conclusions: In our experience, treatment with cyclosporine for steroid-refractory UC during pregnancy can be considered safe and effective. (Inflamm Bowel Dis 2009;1.5:1044-1048)
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