期刊
INFLAMMATORY BOWEL DISEASES
卷 14, 期 10, 页码 1443-1452出版社
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.20449
关键词
innate immune system in IBD; inflammation in IBD; neutrophil; phagocyte
资金
- Wellcome Trust
Inflammatory bowel diseases tire common chronic inflammatory disorders. The majority are idiopathic and can be broadly divided into Crohn's disease and ulcerative colitis. Their cause is unknown. but most hypotheses focus on a primary role for T-cell dysfunction. Conversely. there is a collection of congenital disorders of phagocyte function that result not only in immunodeficiency but also in noninfectious inflammatory bowel disease. In all cases. the latter is strikingly reminiscent of the clinical and pathological features of Crohn's disease. This coincides with recent work demonstrating that despite previous emphasis on adaptive immune dysfunction. patients with Crohn's disease actually possess an unusually weak acute innate inflammatory response. This review Consolidates the literature On inflammatory bowel disease in congenital immunodeficiency and considers the role of phagocyte dysfunction in Crohn's disease. Concept, about pathogenesis and treatment that can be carried across these disorders are also discussed. (Inflamm Bowel Dis 2008; 14:1443-1452)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据